Keith Chater

Recent publications

Aínsa, J.A., Bird, N., Ryding, N.J., Findlay, K.C. and Chater, K.F. (2010) The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2). Antonie Van Leeuwenhoek. 98(2): 225-236.

Chater, K.F., Biró, S., Lee, K.J., Palmer, T. and Schrempf, H. (2009) The complex extracellular biology of Streptomyces. FEMS Microbiol Rev. 34(2): 171-198.

Chater, K.F. (2009) Bacterial extracellular biology. FEMS Microbiol Rev. 34(2): 87-88.

Young, M., Artsatbanov, V., Beller, H.R., Chandra, G., Chater, K.F., Dover, L.G., Goh, E.B., Kahan, T., Kaprelyants, A.S., Kyrpides, N., Lapidus, A., Lowry, S.R., Lykidis, A., Mahillon, J., Markowitz, V., Mavrommatis, K., Mukamolova, G.V., Oren, A., Rokem, J.S., Smith, M.C., Young, D.I. and Greenblatt, C.L. (2009) Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium. J Bacteriol. 192(3): 841-860.

O'Rourke, S., Wietzorrek, A., Fowler, K., Corre, C., Challis, G.L. and Chater, K.F. (2009) Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Molecular Microbiology. 71: 763-778.

Corre, C., Song, L., O'Rourke, S., Chater, K.F. and Challis, G.L. (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci U S A. 105: 17510-17515.

Kim, D.W., Hesketh, A., Kim, E.S., Song, J.Y., Lee, D.H., Kim, I.S., Chater, K.F. and Lee, K.J. (2008) Complex extracellular interactions of proteases and a protease inhibitor influence multicellular development of Streptomyces coelicolor. Molecular Microbiology. 70: 1180-1193.

Kim, E.S., Song, J.Y., Kim, D.W., Chater, K.F. and Lee, K.J. (2008) A Possible Extended Family of Regulators of Sigma Factor Activity in Streptomyces coelicolor. Journal of Bacteriology. 190: 7559-7566.

Kiss, Z., Ward, A. C., Birkó, Z., Chater, K. F. and Biró, S. (2008) Streptomyces griseus 45H, a producer of the extracellular autoregulator protein factor C, is a member of the species Streptomyces albidoflavus. International Journal of Systematic and Evolutionary Microbiology. 58: 1029-1031.

Xu, H., Chater, K. F., Deng, Z. and Tao, M. (2008) A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in streptomyces. Journal of Bacteriology. 190: 4971-4978.

Chater, K. F., Chandra, G. (2008) The use of the rare UUA codon to define "expression space" for genes involved in secondary metabolism, development and environmental adaptation in streptomyces. J Microbiol. 46: 1-11.

Chandra, G. and Chater, K. F. (2008) Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA. Antonie Van Leeuwenhoek. 94: 111-126.

Chater, K. F. and Kinashi, H. (2007) Streptomyces linear plasmids: their discovery, functions, interactions with other replicons, and evolutionary significance. Microbial Monographs, Volume 7: Microbial Linear Plasmids. p.1-31.

Noens, E. E., Mersinias, V., Willemse, J., Traag, B. A., Laing, E., Chater, K. F., Smith, C. P., Koerten, H. K. and van Wezel, G. P. (2007) Loss of the controlled localization of growth stage-specific cell-wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor. Molecular Microbiology. 64: 1244-1259.

Jakimowicz, D., Zydek, P., Kois, A., Zakrzewska-Czerwinska, J. and Chater, K. F. (2007) Alignment of multiple chromosomes along helical ParA scaffolding in sporulating Streptomyces hyphae. Molecular Microbiology. 65: 625-641.

Hesketh, A., Bucca, G., Laing, E., Flett, F., Hotchkiss, G., Smith, C. P. and Chater, K. F. (2007) New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures. BMC Genomics. 8: (article 261).

Ventura, M., Canchaya, C., Tauch, A., Chandra, G., Fitzgerald, G. F., Chater, K. F. and van Sinderen, D. (2007) Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiology & Molecular Biology Reviews. 71: 495-548.

Tian, Y., Fowler, K., Findlay, K. , Tan, H. and Chater, K. F. (2007) An unusual response regulator influences sporulation at early and late stages in Streptomyces coelicolor. Journal of Bacteriology. 189: 2873-2885.

Pawlik, K ., Kotowska, M., Chater, K. F., Kuczek, K. and Takano, E. (2007) A cryptic polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Archives of Microbiology. 187: 87-99.

Wang, L., Yu, Y., He, X ., Zhou, X., Deng, Z., Chater, K. F. and Tao, M. (2007) Role of an FtsK-like protein in genetic stability in Streptomyces coelicolor A3(2). Journal of Bacteriology. 189: 2310-2318.

Li, W., Wu, J., Tao, W., Zhao, C., Wang, Y., He, X., Chandra, G., Zhou, X., Deng, Z., Chater, K. F. and Tao, M. (2007) A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiology Letters. 266: (1) 20-28.

Gust, B., O'Rourke, S. J., Bird, N., Kieser, T. and Chater, K. (2006) Recombineering in Streptomyces coelicolor. FEMS Online Protocols.

Li, W., Ying, X., Guo, Y., Zhou, X., Deng, Z., Kieser, H., Chater, K. F. and Tao, M. (2006) Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2). Journal of Bacteriology. 188: (24) 8368-8375.

Bushell, M. E., Sequeira, S. I. P., Khannapho, C., Zhao, H., Chater, K. F., Butler, M. J., Kierzek, A. M. and Avignone-Rossa, C. A. (2006) The use of genome scale metabolic flux variability analysis for process feed formulation based on an investigation of the effects of the zwf mutation on antibiotic production in Streptomyces coelicolor. Enzyme and Microbial Technology. 39: (6) 1347-1353.

Ruban-Ośmiałowska, B., Jakimowicz, D., Smulczyk-Krawczyszyn, A., Chater, K. F. and Zakrzewska-Czerwinska, J. (2006) Replisome localization in vegetative and aerial hyphae of Streptomyces coelicolor. Journal of Bacteriology. 188: (20) 7311-7316.

Smulczyk-Krawczyszyn, A., Jakimowicz, D., Ruban-Ośmiałowska, B., Zawilak-Pawlik, A., Majka, J., Chater, K. and Zakrzewska-Czerwinska, J. (2006) A cluster of DnaA boxes involved in the regulation of Streptomyces chromosome replication: from in silico to in vivo studies. Journal of Bacteriology. 188: (17) 6184-6194.

Chater, K. F. and Chandra, G. (2006) The evolution of development in Streptomyces analysed by genome comparisons. FEMS Microbiology Reviews. 30: (5) 651-672.

Bralley, P., Gust, B., Chang, S., Chater, K. F. and Jones, G. H. (2006) RNA 3'-tail synthesis in Streptomyces: in vitro and in vivo activities of RNase PH, the SCO3896 gene product and polynucleotide phosphorylase. Microbiology. 152: (3) 627-636.

Chater K. F. (2006) Streptomyces inside out: a new perspective on the bacteria that provide us with antibiotics. Philosophical Transactions of the Royal Society Series B. 361: (1469) 761-768.

Khodakaramian, G., Lissenden, S., Gust, B., Hoskisson, P. A., Chater, K. F. and Smith, M. C. M. (2006) Expression of Cre recombinase during transient phage infection permits efficient marker removal in Streptomyces. Nucleic Acids Research 34: (3) e20

Jakimowicz, D., Mouz, S., Zakrzewska-Czerwinska, Z. and Chater, K. F. (2006) Regulation of developmentally controlled parAB promoter leading to formation of ParB complexes in Streptomyces coelicolor aerial hyphae. Journal of Bacteriology 188: (5) 1710-1720.

Takano, E., Kinoshita, H., Mersinias, V., Bucca, G., Hotchkiss, G., Nihira, T., Smith, C. P. , Bibb, M., Wohlleben, W. and Chater, K. (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor A3(2). Molecular Microbiology. 56: (2) 465-479

Eustaquio, A. S., Gust, B., Galm, U., Li, S-M., Chater, K. F. and Heide, L. (2005) Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters. Applied and Environmental Microbiology. 71: (5) 2452-2459.

Jakimowicz, D., Gust, B., Zakrzewska-Czerwinska, J. and Chater, K. F. (2005) Developmental-stage-specific assembly of ParB complexes in Streptomyces coelicolor hyphae. Journal of Bacteriology. 187: (10) 3572-3580

Kim, D-W., Chater, K., Lee, K-J. and Hesketh, A. (2005) Changes in the extracellular proteome caused by the absence of the bldA gene product, a developmentally significant tRNA, reveal a new target for the pleiotropic regulator AdpA in Streptomyces coelicolor. Journal of Bacteriology. 187: (9) 2957-2966

Garwood, K., McLaughlin, T., Garwood, C., Joens, S., Morrison, N., Taylor, C. F., Carroll, K., Evans, C., Whetton, A. D., Hart, S., Stead, D., Yin, Z., Brown, A. J. P., Hesketh, A., Chater, K., Hansson, L., Mewissen, M. and Ghazal, P. (2005) PEDRo: A database for storing, searching and disseminating experimental proteomics data. BMC Genomics. 5: 68-79.

Takano, E., Kinoshita, H., Mersinias, V., Bucca, G., Hotchkiss, G., Nihira, T., Smith, C. P., Bibb, M. J., Wohlleben, W. and Chater K. (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Molecular Microbiology. 56: (2) 465-479.

Yeo, M. and Chater, K. (2005) The interplay of glycogen metabolism and differentiation provides an insight into the developmental biology of Streptomyces coelicolor. Microbiology. 151: (3) 855-861

Kim, D.W., Chater, K.F., Lee, K.J. and Hesketh, A. (2005) Effects of growth phase and the developmentally significant bldA-specified tRNA on the membrane-associated proteome of Streptomyces coelicolor. Microbiology 151: 2707-2720

Jakimowicz, P., Cheesman, M.R., Bishai, W.R., Chater, K.F., Thomson, A.J., Buttner, M.J. (2005). Evidence that the streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster. J Biol Chem. 280: 8309-8315.

Eustaquio, A.S., Gust, B., Li, S.M., Pelzer, S., Wohlleben, W., Chater, K.F., Heide, L. (2004) Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered Streptomyces coelicolor strains. Chem Biol. 11: (11) 1561-1572.

Gust, B., Chandra, G., Jakimowicz, D., Yuqing, T., Bruton, C.J. and Chater, K.F.(2004) lambda Red-Mediated Genetic Manipulation of Antibiotic-Producing Streptomyces. Adv.Appl.Microbiol. 54:107-128.

Bentley, S.D., Brown, S., Murphy, L.D., Harris, D.E., Quail, M.A., Parkhill, J., Barrell, B.G., McCormick, J.R., Santamaria, R.I., Losick, R., Yamasaki, M., Kinashi, H., Chen, C.W., Chandra, G., Jakimowicz, D., Kieser, H.M., Kieser, T. and Chater, K.F.(2004) SCP1, a 356,023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2). Molecular Microbiology 51: (6) 1615-1628.

Yamasaki, M., Ikuto, Y., Ohira, A., Chater, K. and Kinashi, H. (2003) Limited regions of homology between linear and circular plasmids encoding methylenomycin biosynthesis in two independently isolated streptomycetes. Microbiology 149: 1351-1356.

Chater, K.F. and Horinouchi, S. (2003) Signalling early developmental events in two highly diverged Streptomyces species. Molecular Microbiology 48: 9-15.

Chater, K.F., Bucca, G., Dyson, P., Fowler, K., Gust, B., Herron, P., Hesketh, A, Hotchkiss, G., Kieser, T., Mersinias, V. and Smith, C.P. (2002) Streptomyces coelicolor A3(2) from genome sequence to function. Methods in Microbiology 33: (17) 321-336.

Hesketh, A.R., Chandra, G., Shaw, A.D., Rowland, J.J., Kell, D.B., Bibb, M.J. and Chater, K.F. (2002) Primary and secondary metabolism and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor. Molecular Microbiology 46: (4) 917-932.

Jakimowicz, D., Chater, K.F. and Zakrzewska-Czerwinska, J.(2002) The ParB protein of Streptomyces coelicolor A3(2) recognises a cluster of parS sequences within the origin-proximal region of the linear chromosome. Molecular Microbiology 45: (5) 1365-1370.

Hesketh, A., Fink, D., Gust, B., Rexer, U., Scheel, B., Chater, K., Wohlleben, W. and Engels, A. (2002) The GlnD and GlnK homologues of Streptomyces coelicolor A3(2) are functionally dissimilar to their nitrogen regulatory system counterparts from enteric bacteria. Mol.Microbiol. 46: (2) 319-330.

Bentley, S.D., Chater, K.F., Cerdeno-Tarraga, A.M., Challis, G.L., Thomson, N.R., James, K.D., Harris, D.E., Quail, M.A., Kieser, H., Harper, D., Bateman, A., Brown, S., Chandra, G., Chen, C.W., Collins, M., Cronin, A., Fraser, A., Goble, A., Hidalgo, J., Hornsby, T., Howarth, S., Huang, C.H., Kieser, T., Larke, L., Murphy, L., Oliver, K., O'Neil, S., Rabbinowitsch, E., Rajandream, M.A., Rutherford, K., Rutter, S., Seeger, K., Saunders, D., Sharp, S., Squares, R., Squares, S., Taylor, K., Warren, T., Wietzorrek, A., Woodward, J., Barrell, B.G., Parkhill, J. and Hopwood, D.A. (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) Nature 417: 141-147.

Challis, G.L. and Chater, K.F. (2001) Incorporation of [U-13C] glycerol defines plausible early steps for the biosynthesis of methylenomycin A in Streptomyces coelicolor A3(2) Chemical Communications.

Chater, K.F. (2001) Regulation of sporulation in Streptomyces coelicolor A3(2): a checkpoint multiplex? Curr.Opin.Microbiol. 4: 667-673.

Yang, H., Tian, Y., Jia, J., Tan, H. and Chater, K. F. (2000) The Function Of A Regulatory Gene, Scrx Related To Differentiation In Streptomyces Coelicolor. Science In China 43: 157-168.

Hahn, J.S., Oh, S.Y., Chater, K.F., Cho, Y.-H. and Roe, J.H. (2000) H2o2-Sensitive Fur-Like Repressor Catr Regulating The Major Catalase Gene In Streptomyces Coelicolor. J. Biol. Chem. 275: 38254-38260.

Ainsa, J.A., Ryding, N.J., Hartley, N., Findlay, K.C., Bruton, C.J. and Chater, K.F. (2000) Whia, A Protein Of Unknown Function Conserved Among Gram-Positive Bacteria, Is Essential For Sporulation In Streptomyces Coelicolor A3(2) J.Bacteriol. 182: 5470-5478.

Bignell, D.R., Warawa, J.L., Strap, J.L., Chater, K.F. and Leskiw, B.K. (2000) Study Of The Bldg Locus Suggests That An Anti-Anti-Sigma Factor And An Anti-Sigma Factor May Be Involved In Streptomyces Coelicolor Antibiotic Production And Sporulation Microbiology 146: ( Pt 9) 2161-2173.

Flardh, K., Leibovitz, E., Buttner, M.J. and Chater, K.F. (2000) Generation Of A Non-Sporulating Strain Of Streptomyces Coelicolor A3(2) By The Manipulation Of A Developmentally Controlled Ftsz Promoter. Molecular Microbiology 38: 737-749.

Kim, H-J., Calcutt, M. J., Schmidt, F. J. and Chater, K. F. (2000) Partitioning of the linear chromosome during sporulation of Streptomyces coelicolor A3(2) involves an oriC-linked paraB locus. Journal of Bacteriology, 182: 1313-1320.

Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F. and Hopwood, D. A. (2000) Practical Streptomyces Genetics. Norwich, John Innes Foundation.

Schneider, D., Bruton, C. J. and Chater, K. F. (2000) Duplicated gene clusters suggest an interplay of glycogen and trehalose metabolism during sequential stages of aerial mycelium development in Streptomyces coelicolor A3(2) Mol Gen Genet 263: 543-553.

Soliveri, J. A., Gomez, J., Bishai, W. R. and Chater, K. F. (2000) Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes. Microbiology 146: 333-343.

Chater, K. F. (2000) Developmental decisions during sporulation in the aerial mycelium in Streptomyces. In: Prokaryotic Development (Eds: Brun, Y V, Shimkets, L J). American Society for Microbiology 2: 33-48.

Soliveri, J., Scheu, A. K., Hernandez, A., Copa-Patino, J. L. and Chater, K. F. (1999) Faster recombinant DNA procedures for Streptomyces. Biotechniques, 26: 394-396.

Liu, G., Tian, Y., Yang, H., Chen, W., Tan, H., Chater, K. F., Buttner, M. J. (1999) A novel gene – sawD related to the differentiation of Streptomyces ansochromogenes. Chinese Journal of Biotechnology, 15: 415-421.

Tian, Y., Liu, G., Nie, L., Jia, J., Tan, H. and Chater, K. F. (1999) A novel gene – samfR involved in early stage of Streptomyces ansochromogenes differentiation. Science in China, 42: 570-576.

Chater, K. F. (1999) David Hopwood and the emergence of Streptomyces genetics. Internatl. Microbiol. 2: 61-68.

Chater, K. F. and Nikaido, H. (1999) Cell regulation: Maintaining integrity and efficiency in microbial cells. Curr. Opin. Microbiol. 2: 121-125.

Vincente, M., Chater, K. F. and De Lorenzo, V. (1999) Bacterial transcription factors involved in global regulation. Molecular Microbiology, 33: 8-17.

Flärdh, K., Findlay, K. C. and Chater, K. F. (1999) Association of early sporulation genes with suggested developmental decision points in Streptomyces coelicolor A3(2). Microbiology, 145: 2229-2243.

Aínsa, J. A., Parry, H. D., Chater, K. F. (1999) A response regulator-like protein that functions at an intermediate stage of sporulation in Streptomyces coelicolor A3(2). Mol. Microbiol. 34: 607-619.

Yudkin, M. D., Chater, K. F. (1999) Integration of control devices. II. Sporulation and antibiotic production. In: Prokaryotic Gene Expression (Ed: Baumberg, S.) Oxford University Press, 281-310.

Ryding, N. J., Bibb, M. J., Molle, V., Findlay, K. C., Chater, K. F., Buttner, M. J. (1999) New sporulation loci in Streptomyces coelicolor A3(2). Journal of Bacteriology, 181: 5419-5425.

Chater, K. F. (1998) Taking a genetic scalpel to the Streptomyces colony. Microbiology, 144: 1465-1478.

Elliot, M., Dmaji, F., Passantino, R., Chater, K. and Leskiw, B. (1998) The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production. Journal of Bacteriology, 180: 1549-1555.

Guthrie, E. P., Flaxman, C. S., White, J., Hodgson, D. A., Bibb, M. J., Chater, K. F., (1998) A response regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket. Microbiology 144: 727-738.

Kelemen, G. H., Brian, P., Flärdh, K., Chater, K. F., Buttner, M. J. (1998) Developmental regulation of the transcription of whiE, a locus specifying the polyktide spore pigment in Streptomyces coelicolor A3(2). Journal of Bacteriology, 180: 2515-2521.

Ryding, N. J., Kelemen, G. H., Whatling, C. A., Flardh, K., Buttner, M. J. and Chater, K. F. (1998) A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3(2). Molecular Microbiology, 29: 343-357.

Tan, H., Yang, H., Tian, Y., Wu, W., Whatling, C. A., Chamberlin, L. C., Buttner, M. J., Nodwell, J. and Chater, K. F. (1998) The Streptomyces coelicolor sporulation-specific ? WhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation. Gene. 212: 137-146.

Aubert, M., Weber, E., Gintz, B., Chater, K. F. and Decaris, B. (1998) Inactivation or amplification of the spa2 gene, encoding a potential stationary-phase regulator, affects differentiation in Streptomyces ambofaciens. Canadian Journal of Microbiology, 43: 1118-1125.

Martin, M. C., Schneider, D., Bruton, C. J., Chater, K. F., Hardisson, C. (1997) A glgC gene essential only for the first of two spatially distinct phases of glycogen synthesis in Streptomyces coelicolor A3(2). J. Bacteriol., 179: 7784-7789.

Oh, S-H and Chater, K. F. (1997) Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3(2): possible relevance to other organisms. J. Bacteriol., 179: 122-127.

Chater, K. F. and Bibb, M. J. (1997) Regulation of Bacterial Antibiotic Production. In: Biotechnology (Eds: Rehm, H -J, Reed) Mannheim pp 149-182.

Chater, K. F., Whatling, C., Ryding, N. J., Parry, H. D., Hartley, N., Kelemen, G. H., Chamberlin, L. C., Buttner, M. J. and Bruton, C. J. (1996) The regulatory network controlling sporulation septation in Streptomyces coelicolor A3(2). Proceeding of EC BIOTECH Workshop on "Regulation of Cell Division in Bacteria of Basic and Applied Interest: an Integrated View", Leon, Spain, 20 - 23 March.

Schneider, D., Bruton, C. J. and Chater, K. F. (1996) Characterization of spaA, a Streptomyces coelicolor gene homologous to a gene involved in sensing starvation in Escherichia coli. Gene, 177: 243-251.

Kelemen, G. H., Brown, G. L., Kormanec, J., Potúková, Chater, K. F. and Buttner, M. J. (1996). The positions of the sigma-factor genes, whiG and sigF, in the hierarchy controlling the development of spore chains in the aerial hyphae of Streptomyces coelicolor A3(2). Molecular Microbiology, 21: 593-603.