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The Moore Lab

Understanding the make-up of the Ph1 complex and its role in chromosome pairing
Professor Graham Moore
Professor Graham Moore [CV]
Our research makes front cover of Nature Our research makes headline news
Nature paper, 2001 Article based on Nature paper, 2006

The Moore Group is currently investigating chromosome pairing in wheat and related species, which is under the control of the Ph1 locus

Understanding the make-up of the Ph1 complex and its role in chromosome pairing has important implications for wheat breeding, as it allows breeders to cross bread wheat with its wild relatives, thus opening up a large pool of desirable traits such as salt tolerance, drought resistance and disease resistance that would be otherwise unavailable.

The molecular characterisation of Ph1 by our group is published in Nature 2006 and Ann. Bot. 2007

In an ongoing collaborative project with Peter Shaw’s group (JIC, Cell & Developmental Biology), we are investigating the mechanism by which the Ph1 locus controls specificity of chromosome pairing in wheat during meiosis.

Chromosome segments (green) and telomeres (red) pairing during early meiosis in wheat in the presence of Ph1
Chromosome segments (green) and telomeres (red) pairing during early meiosis in wheat in the presence of Ph1 - link to meiosis gallery

The group is also interested in other mechanisms that impair or prevent interspecific crossing, such as gametocidal genes and the interspecific crossability locus (Kr1).

 

 

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