Postdoctoral Research Scientist

John Innes Centre, Norwich - Dept Biological Chemistry

The Molecular Basis of the Action of the Antibiotic Simocyclinone D8 on DNA Gyrase
Anthony Maxwell & David M Lawson, Dept Biological Chemistry, John Innes Centre, Norwich, UK

Simocyclinone D8 is a recently-discovered antibiotic that is not currently in clinical use.  We have been able to show that it targets an enzyme in bacteria (DNA gyrase) by a novel mechanism.  We aim to understand this mechanism of action in detail in order to reveal principles of drug-target interaction that will be applicable to other systems.  We anticipate that this knowledge will provide information that will be used, particularly in the pharmaceutical industry, in the design of more-potent, more-specific antibiotics that will avoid current resistance problems.

Candidates should have a PhD in Biochemistry/Biophysics/Molecular Biology or a related discipline with previous experience in a related area of research.  The ability to work independently when required and learn new techniques is essential.  The postholder should also be prepared to work as part of a larger team.  Experience in biochemistry/crystallography/molecular biology/genetics is desirable.  We will be providing the job-holder with opportunities to develop their technical and transferable skills, by way of training programmes, coaching and mentoring.  Candidates who have up to three years postdoctoral experience will be appointed under the Postdoctoral Training Fellowship scheme: http://www.jic.ac.uk/corporate/opportunities/PDTF.html.

Edwards, M.J. et al. A crystal structure of the bifunctional antibiotic, simocyclinone D8, bound to DNA gyrase. Science 326, 1415-1418 (2009).

Salary on appointment will be within the range £26,610 to £29,566 per annum depending on qualifications and experience (Please note a new pay and grading system will be implemented from 1 April 2011, information is provided in our further particulars on the website).

For further information and details of how to apply, please visit our web site http://jobs.jic.ac.uk or contact Tony Maxwell (tony.maxwell@bbsrc.ac.uk; 01603 450771).

The closing date for applications will be 31^st March 2011.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

Full details of opportunities at JIC

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