Publications
Le, T. B. K., Stevenson, C. E. M., Fiedler, H.-P., Maxwell, A., Lawson D. M. & Buttner, M. J. Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression. J. Mol. Biol., in press.
Le, T. B. K., Stevenson, C. E. M., Buttner, M. J. & Lawson D. M. (2011). Crystallization and preliminary X-ray analysis of the TetR-like efflux pump regulator SimR. Acta Cryst., F67, 307-309.
Ashby, J. A., Stevenson, C. E. M., Lawson, D. M. & Maule, A. J. (2011). Structure-based mutational analysis of eIF4E in relation to sbm1 resistance to Pea seed-borne mosaic virus in pea. PLoS ONE, 6, e15873.
Rejzek, M., Stevenson, C. E., Southard, A. M., Stanley, D., Denyer, K., Smith, A. M., Naldrett, M. J., Lawson, D. M., & Field, R. A. (2011). Chemical genetics and cereal starch metabolism: structural basis of the non-covalent and covalent inhibition of barley β-amylase. Molecular Biosystems, 7, 718-730.
Metzger, U., Keller, S., Stevenson, C. E. M., Heide, L. & Lawson, D. M. (2010). Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway. J. Mol. Biol., 404, 612-626.
Gómez García, I., Stevenson, C.
E., Usón, I., Meyers, C. L., Walsh, C. T. & Lawson,
D. M. (2010). The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase
superfamily. J.
Mol. Biol., 395, 390-407.
Edwards, M. J., Flatman,
R. H., Mitchenall, L. A., Stevenson, C. E. M., Le, T. B. K., Clarke, T. A.,
McKay, A. R., Fiedler, H.-P., Buttner, M. J., Lawson, D. M. & Maxwell, A. (2009). A crystal structure of the bifunctional
antibiotic, simocyclinone D8, bound to DNA gyrase. Science, 326, 1415-1418.
Gunasekaran P., Grandison G., Cowtan K., Mak L., Lawson D. M., Morris R. J. (2009) Ligand Electron Density Shape Recognition Using 3D Zernike Descriptors Sheffield, Pattern Recognition in Biology, 7-9 Sept 2009 Springer Berlin / Heidelberg 125-136.
Edwards, M. J., Flatman, R. H., Mitchenall, L. A., Stevenson, C. E., Maxwell, A. & Lawson, D. M. (2009). Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase. Acta Cryst. F65, 846-848.
Ashby, J. A., Stevenson, C. E., Maule, A. J. & Lawson, D. M. (2009). Crystallization and preliminary X-ray analysis of eukaryotic initiation factor 4E from Pisum sativum. Acta Cryst. F65, 836-838.
Gómez García,
I., Freel Meyers, C. L., Walsh, C. T. & Lawson,
D. M. (2008). Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase
NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides.
Acta Cryst.
F64, 1000-1002.
Tello, M., Rejzek, M., Wilkinson, B., Lawson,
D. M. & Field, R. A. (2008). Tyl1a, a dTDP-6-deoxy-D-xylo-4-hexulose 3,4-isomerase
from Streptomyces fradiae: structure prediction, mutagenesis and
solvent isotope incorporation experiments to investigate reaction mechanism. ChemBioChem, 9, 1295-1302.
Just, V. J., Burrell, M. R., Bowater, L., McRobbie,
Usón,
Burman, J. D., Stevenson, C. E.
M., Sawers, R. G. & Lawson, D. M. (2007). The crystal structure of Escherichia coli TdcF,
a member of the highly conserved YjgF/YER057c/UK114 family. BMC Struct. Biol., 7, 30.
Stevenson, C. E. M., Kock, H., Mootien, S., Davies, S.
C., Bibb, M. J. & Lawson, D. M. (2007). Crystallization and
preliminary X-ray analysis of AbsC, a novel regulator
of antibiotic production in Streptomyces coelicolor. Acta Cryst., F63, 233-235.
Stevenson, C. E. M., Freel Meyers, C. L., Walsh, C. T. & Lawson, D. M.
(2007). Crystallization and preliminary X-ray analysis of the O-methyltransferase NovP
from the novobiocin-biosynthetic cluster of Streptomyces
spheroides. Acta Cryst., F63, 236-238.
Keller, S., Pojer,
F., Heide, L. & Lawson, D. M. (2006). Molecular
replacement in the "twilight zone": crystal structure determination
of the non-heme iron oxygenase NovR
from Streptomyces spheroides
through repeated density modification of a poor molecular replacement solution.
Acta Cryst., D62,
1564-1570.
Keller, S., Pojer, F., Heide, L. & Lawson, D. M. (2006). Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes. Acta Cryst., F62, 1153-1155.
Stevenson, C. E. M., Burton, N., Costa, M. M., Nath, U., Dixon, R. A., Coen, E.
S. & Lawson, D. M. (2006).
Jakimowicz, P., Tello,
M., Freel Meyers, C. L., Walsh, C. T., Buttner, M. J., Field, R. A. & Lawson, D. M. (2006). The 1.6 Å resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin
biosynthetic gene cluster of Streptomyces
spheroides. Proteins:
Structure, Function and Bioinformatics, 63, 261-265.
Tello, M., Jakimowicz,
P., Errey, J. C., Freel
Meyers, C. L., Walsh, C. T., Buttner, M. J., Lawson,
D. M. & Field, R. A. (2006). Characterisation of Streptomyces
spheroides
NovW and revision of its functional assignment to a
dTDP-6-deoxy-d-xylo-4-hexulose
3-epimerase. Chem. Comm.,
1079-1081.
Stevenson, C. E. M.,
Stevenson, C. E. M., Tanner, A., Bowater, L., Bornemann, S. & Lawson, D. M. (2004). SAD at home: solving the structure of oxalate decarboxylase with the anomalous signal from manganese using X-ray data collected on a home source. Acta Cryst., D60, 2403-2406.
Burman, J. D., Harris, R. L., Hauton, K. A., Lawson, D. M. & Sawers, R. G. (2004). The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity. FEBS Lett., 576, 442-444.
Just, V. J., Stevenson, C. E. M., Bowater, L., Tanner, A., Lawson, D. M. & Bornemann, S. (2004). A closed conformation of Bacillus subtilis oxalate decarboxylase OxdC provides evidence for the true identity of the active site. J. Biol. Chem. 279, 19867-19874.
Bornemann, S., Lawson, D. M. & Thorneley, R. N. (2003). A Branch Point in Chorismate Synthase Research. Structure, 11, 1463-1465.
Jakimowicz, P., Freel Meyers, C. L., Walsh, C. T., Buttner, M. J. & Lawson, D. M. (2003). Crystallization and preliminary X-ray studies on the putative dTDP sugar epimerase NovW from the novobiocin biosynthetic cluster of Streptomyces spheroides. Acta Cryst., D59, 1507-1509.
Güse, A., Stevenson, C. E. M., Kuper, J., Buchanan, G., Schwarz, G., Giordano, G., Magalon, A., Mendel, R. R., Lawson, D. M. & Palmer, T. (2003). Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA. J. Biol. Chem., 278, 25302-25307.
Lawson, D. M., Stevenson, C. E. M., Andrew, C. R., George, S. J. & Eady, R. R. (2003). A two-faced molecule offers NO explanation: the proximal binding of nitric oxide to heme. Biochem. Soc. Trans., 31, 553-557.
Burman, J. D., Stevenson, C. E. M., Hauton, K. A., Sawers, G. & Lawson, D. M. (2003). Crystallisation and preliminary X-ray analysis of the E. coli hypothetical protein TdcF. Acta Cryst., D59, 1076-1078.
Strange R. W., Smith B. E., Eady R. R., Lawson D. & Hasnain S. S. (2003). XAFS studies of nitrogenase: the MoFe and VFe proteins and the use of crystallographic coordinates in three-dimensional EXAFS data analysis. J. Synch. Rad., 10, 71-75.
Maxwell, A. & Lawson, D.M. (2003). The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr. Top. Med. Chem., 3, 283-303.
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