Publications:

 

CLEMENTE, A., MARÍN-MANZANO, M. C. and DOMONEY, C. Exploiting natural variation in legume Bowman-Birk inhibitors to dissect their potential role in human health-promoting programmes. Can. J. Plant Sci.91, 377-378, 2011.

CLEMENTE, A., SONNANTE, G. and DOMONEY, C. Nutritional implications of Bowman-Birk inhibitors from legumes and human gastrointestinal health: current status and perspectives. Curr. Prot. Pep. Sci. 12, 358-373, 2011.

CLEMENTE, A., RUBIO, L.A., MARÍN-MANZANO, M.C., JIMÉNEZ, E. and DOMONEY, C. Chemopreventive properties of dietary Bowman-Birk inhibitors from legumes. Amino Acids 37, S106, 2009.

DOMONEY, C., CHARLTON, A., CHINOY, C., VIGEOLAS, H., GEIGENBERGER, P. and CLEMENTE, A. Manipulating seed quality traits in pea (Pisum sativum L.) for improved feed and food. Grain Legumes 52, 12-13, 2009.

DOMONEY, C., CHINOY, C., LAUGIER, F., PILLINGER, W., CHARLTON, A. and CLEMENTE, A. The challenge of manipulating seed quality traits in pea for multiple end uses. Pisum Genet. 41, 48, 2009.

CLEMENTE, A., MORENO, F. J., MARÍN-MANZANO, M. C., JIMÉNEZ, E. and DOMONEY, C. The cytotoxic effect of Bowman-Birk isoinhibitors from soybean (Glycine max) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases. Mol. Nutr. Food Res. 54, 396-405, 2010.

DOMONEY, C., CHINOY, C., PILLINGER, W., HASENKOPF, K., WILD, F., WARKENTIN, T., CLEMENTE, A. and CHARLTON, A. The genetic control of seed quality traits that impact on food and feed uses of pea. In: Legumes for global health, Legume crops and products for food, feed and environmental benefits. Abstract (Keynote) of the Fifth International Food Legumes Research Conference (IFLRC V) & Seventh European Conference on Grain Legumes (AEP VII), Antalya, Turkey, p. 53, 2010.

CLEMENTE, A., MARÍN-MANZANO, M. C., JIMÉNEZ, E. SONNANTE, G., MORENO, F. J., RUBIO, L. A. and DOMONEY, C. The cytotoxic effects of Bowman-Birk proteins from legumes on colon cancer cells are related to their ability to inhibit serine proteases. In: Legumes for global health, Legume crops and products for food, feed and environmental benefits. Abstract of the Fifth International Food Legumes Research Conference (IFLRC V) & Seventh European Conference on Grain Legumes (AEP VII), Antalya, Turkey, p. 22, 2010.

KNOX, M., DOMONEY, C., COYNE, C., AMBROSE, M. and ELLIS, N. Relationship patterns in Pisum assessed with a range of molecular marker types. In: Legumes for global health, Legume crops and products for food, feed and environmental benefits. Abstract of the Fifth International Food Legumes Research Conference (IFLRC V) & Seventh European Conference on Grain Legumes (AEP VII), Antalya, Turkey, p. 159, 2010.

CLEMENTE, A., MARÍN-MANZANO, M. C., JIMÉNEZ, E., MORENO, F. J., RUBIO, L. A. and DOMONEY, C. The anti-proliferative properties of Bowman-Birk proteins from legumes on colon cancer cells are related to their ability to inhibit trypsin- and chymotrypsin-like proteases. In: Abstracts of the BIT Inaugural Symposium on Enzymes & Biocatalysts, Shanghai, China, p. 173, 2010.

RUBIALES, D., AMBROSE, M. J., DOMONEY, C. and BURSTIN, J. Pea (Pisum sativum L.). In: Genetics, Genomics and Breeding in Crop Plants: Cool Season Food Legumes (Ed. Kole, C.). Science Pubs Inc., New Hampshire, Jersey, Plymouth, 2010 (in press).

VIGEOLAS, H., CHINOY, C., ZUTHER, E., BLESSINGTON, B., GEIGENBERGER, P. and DOMONEY, C.  Combined metabolomic and genetic approaches reveal a link between the polyamine pathway and albumin 2 in developing pea seeds. Plant Physiology 146, (1) 74-82, 2008.

CHARLTON, A. J., DONARSKI, J. A., HARRISON, M., JONES, S. A., GODWARD, J., OEHLSCHLAGER, S., ARQUES, J. L., AMBROSE, M., CHINOY, C., MULLINEAUX, P. M., DOMONEY, C. Responses of the pea (Pisum sativum L.) leaf metabolome to drought stress assessed by nuclear magnetic resonance spectroscopy. Metabolomics 4 (4) 312-327 DOI: 10.1007/s11306-008-0128-0, 2008.

CLEMENTE, A. and DOMONEY, C. Therapeutic properties of legume protease inhibitors from the Bowman-Birk family. In: Recent Progress in Medicinal Plants 20. (Ed. J.N. Govil and V.K. Singh). Studium Press LLC, Tx, USA, pp. 397-417, 2007.

ZHUKOV, V.A., KUZNETSOVA, E.V., OVCHINNIKOVA, E.S., RYCHAGOVA, T.S., TITOV, V.S., PINAEV, A.G., BORISOV, A.Y., MOFFET, M., DOMONEY, C., ELLIS, T.H.N., RATET, P., WEEDEN, N.F. and TIKHONOVICH, I.A. Gene-based markers of pea linkage group V for mapping genes related to symbioses. Pisum Genetics 39, 19-25, 2007.

CLEMENTE, A. and DOMONEY, C. Biological significance of polymorphism in legume protease inhibitors from the Bowman-Birk family. Curr. Prot. Pep. Sci. 7, 201-216, 2006.

DOMONEY, C. and STITT, M. Improvement of seed protein composition and quantity in grain legumes. Grain Legumes 44, pp. 14-15, 2006.

WISEMAN, J., AL-MARZOOQI, W., HEDLEY, C., WANG, T.L., WELHAM, T. and DOMONEY, C. The effects of genetic variation at r, rb and Tri loci in Pisum sativum L. on apparent ileal digestibility of amino acids in young broilers. J. Sci. Food Agric. 86, 436-444, 2006.

DOMONEY, C., DUC, G, ELLIS, T.H.N., FERRÁNDIZ, C., FIRNHABER, C., GALLARDO, K., HOFER, J., KOPKA, J., KÜSTER, H., MADUEÑO, F., MUNIER-JOLAIN, N.G., MAYER, K., THOMPSON, R., UDVARDI, M. and SALON C. Genetic and genomic analysis of legume flowers and seeds. Curr. Opin. Plant Biol. 9, 133-141, 2006.

DOMONEY, C. and STITT, M. Seed composition and quality in grain legumes. Grain Legumes 41, pp. 18-19, 2005.

 SMEDLEY, M., BEAN, S., CHINOY, C., DOMONEY, C. and HARWOOD, W. Pea transformation as part of the BRACT project. Poster presented at EU GLIP annual meeting, Norwich, 2005.

 KLENELL, M., DOMONEY, C. and MULLINEAUX, P. Identification of genes differentially expressed during drought stress in Pisum sativum. Poster presented at EU GLIP annual meeting, Norwich, 2005.

 CLEMENTE, A. and DOMONEY, C. Therapeutic properties of legume protease inhibitors from the Bowman-Birk family. In: Recent Progress in Medicinal Plants 20. (Ed. J.N. Govil). Studium Press LLC, Tx, USA, pp. xx, 2006.

CLEMENTE, A., GEE, J.M., JOHNSON, I.T., MACKENZIE, D.A. and DOMONEY, C. Pea (Pisum sativum L.) Protease Inhibitors from the Bowman-Birk Class Influence the Growth of Human Colorectal Adenocarcinoma HT29 Cells In Vitro.  J. Agric. Food Chem.  53, pp. 8979-8986, 2005.

CLEMENTE, A., MACKENZIE, D.A., JEENES, D.J. and DOMONEY, C. The effect of variation within inhibitory domains on the activity of pea protease inhibitors from the Bowman-Birk class. Protein Express. Purif. 36, 106-114, 2004.

MUZQUIZ, M., WELHAM, T., ALTARES, P., GOYOAGA, C., CUADRADO, C., ROMERO, C., GUILLAMON, E. and DOMONEY, C. The effect of germination on seed trypsin inhibitors in Vicia faba and Cicer arietinum. J. Sci. Food Agric. 84, pp. 556-560, 2004.

CLEMENTE, A., MACKENZIE, D. A., JOHNSON, I. T. and DOMONEY, C. Investigation of legume seed protease inhibitors as potential anti-carcinogenic proteins. In: Recent advances of research in antinutritional factors in legume seeds and oilseeds. (Eds. M. Muzquiz, G.D. Hill, C. Cuadrado, M.M. Pedrosa and C. Burbano). Wageningen Academic Pubs, Wageningen, pp. 137-141, 2004.

GREINER, R. and DOMONEY, C. The potential of genetically modified legume and oilseed crops for food and non-food use. In: Recent advances of research in antinutritional factors in legume seeds and oilseeds. (Eds. M. Muzquiz, G.D. Hill, C. Cuadrado, M.M. Pedrosa and C. Burbano). Wageningen Academic Pubs, Wageningen, pp. 261-276, 2004.

DUC, G., MARGET, P., PAGE, D. and DOMONEY, C. Facile breeding markers to lower contents of vicine and convicine in faba bean seeds and trypsin inhibitors in pea seeds. In: Recent advances of research in antinutritional factors in legume seeds and oilseeds. (Eds. M. Muzquiz, G.D. Hill, C. Cuadrado, M.M. Pedrosa and C. Burbano). Wageningen Academic Pubs, Wageningen, pp. 281-285, 2004.

CLEMENTE, A., MACKENZIE, D. A., JOHNSON, I. T. and DOMONEY, C. Investigation of legume seed protease inhibitors as potential anti-carcinogenic proteins. In: Proc. Fifth European Conference on Grain Legumes, Dijon, France. (Ed. AEP), pp. 51-52, 2004.

CHARLTON, A., GODWARD, J., OEHLSCHLAGER, S., AMBROSE, M., BOWEN, M., WELHAM, T., MULLINEAUX, P. and DOMONEY, C. Investigation of the metabolome of leaves from a pea germplasm array and from transgenic pea plants exposed to environmental stress. In: Proc. Fifth European Conference on Grain Legumes, Dijon, France. (Ed. AEP), pp. 189-190, 2004.

WANG, T.L., DOMONEY, C., HEDLEY, C.L., CASEY, R. and GRUSAK, M.A. Can we improve the nutritional quality of legume seeds? Plant Physiol. 131, 886-891, 2003.

WISEMAN, J., AL-MAZOOQI, W., WELHAM, T. and DOMONEY, C. The apparent ileal digestibility, determined with young broilers, of amino acids in near-isogenic lines of peas (Pisum sativum L) differing in trypsin inhibitor activity. J. Sci. Food Agric. 83, 644-651, 2003.

PAGE, D., DUC, G., LEJEUNE-HENAUT, I. and DOMONEY, C. Marker-assisted selection of genetic variants for seed trypsin inhibitor content in peas. Pisum Genet. 35, 19-21, 2003.

CLEMENTE, A., MACKENZIE, D., JEENES, D., GEE, J., JOHNSON, I. and DOMONEY, C. Anticarcinogenic properties of plant protease inhibitors from the Bowman-Birk class. In: Plant Biotechnology 2002 and Beyond. (Ed. Vasil, I.K.). Kluwer Academic Pub., The Netherlands, pp.429-431, 2003.

GODWARD, J., CHARLTON, A., OEHLSCHLAGER, S., CHISHOLM, J., MULLINEAUX, P., BOWEN, M., AMBROSE, M., DOMONEY, C., GEORGE, C. and ASTWOOD, J. NMR investigation of the metabolome of leaves from a germplasm array and transgenic pea plants exposed to environmental stresses. In: Abstr. Second International Conference on Plant Metabolomics, Potsdam, Germany, p.49, 2003.

DOMONEY, C., WELHAM, T., ELLIS, N., MOZZANEGA, P. and TURNER, L. Three classes of proteinase inhibitor gene have distinct but overlapping patterns of expression in Pisum sativum plants. Plant Mol. Biol. 48, 319-329, 2002.

PAGE, D., AUBERT, G., DUC, G., WELHAM, T. and DOMONEY, C. Combinatorial variation in coding and promoter sequences of genes at the Tri locus in Pisum sativum accounts for variation in trypsin inhibitor activity in seeds. Mol. Genet. Genomics 267, 359-369, 2002.

CASEY, R., CHRISTOU, P., DOMONEY, C., HEDLEY, C., HITCHIN, E., PARKER, M., STOGER, E., WANG, T. and ZASIURA, C. Expression of legumin and vicilin genes in pea mutants and the production of legumin in transgenic plants. Nahrung/Food 45, 385-387, 2001.

PAGE, D., AUBERT, G., DUC, G., WELHAM, T. and DOMONEY, C. Identification and exploitation of seed trypsin inhibitor gene polymorphism for molecular marker-assisted breeding and selection. In: Proc. Fourth European Conference on Grain Legumes, Cracow, Poland. (Ed. AEP), pp. 20-21, 2001.

WELHAM, T. and DOMONEY, C. Improvement of pea (Pisum sativum) seed protein quality through biotechnology. In: Proc. Fourth European Conference on Grain Legumes, Cracow, Poland. (Ed. AEP), pp. 86-87, 2001.

CLEMENTE, A. and DOMONEY, C. Anticarcinogenic activity of protease inhibitors in legumes. In: Proc. Fourth European Conference on Grain Legumes, Cracow, Poland. (Ed. AEP), pp. 114-115, 2001.

DOMONEY, C. Novel approaches for the determination of individual constituents in grain seeds. Grain Legumes 34, 14-15, 2001.

WELHAM, T. and DOMONEY, C. Temporal and spatial activity of a promoter from a pea enzyme inhibitor gene and its exploitation for seed quality improvement. Plant Science 159, 289-299, 2000.

DOMONEY, C., WELHAM, T. and MOZZANEGA, P. Expression and genetical analysis of a multigene family encoding inhibitors in seed and non-seed organs of pea (Pisum sativum L.). In: Molecular Genetics of Model Legumes - impact for legume biology and breeding (EuroConference Abstracts), p.82, 2000.

CASEY, R., DOMONEY, C., HEDLEY, C., HITCHIN, E., WANG, T. and ZASIURA, C. The effect of carbon metabolism on seed protein gene expression during seed development in legumes. In: Molecular Genetics of Model Legumes - impact for legume biology and breeding (EuroConference Abstracts), p.24, 2000.