Host responses to virus replication

Viruses rely completely on host metabolism for the synthesis of viral proteins and nucleic acids. Accordingly, they develop an intimate relationship that can influence the balance in host cell metabolism (see e.g. Maule et al., 2002). Viruses also exploit cellular structure and development, for example in exploiting plasmodesmata and the vasculature to assist virus movement. These effects may be mediated by specific viral gene products or by more generic influences (e.g. metabolic pressure) on the host cell.

See:

• Spatial and temporal changes in host gene expression after virus infection
• Virus infection triggers the cytoplasmic protein response