Stephen Bornemann
Associate Head of Department
Biological Chemistry
Contact details
Tel: +44 (0)1603 450741
stephen.bornemann@bbsrc.ac.uk
Research interests
Our current lines of enquiry include starch and polyglucan biosynthesis in plants and microbes, and symbiosis signalling in plants. We are a multidisciplinary group that studies enzymes at the atomic level using biochemical and biophysical methods along with complementary molecular biology approaches to address physiological function. Enzymes that have been studied previously include cupins, such as oxalate-degading enzymes, and chorismate synthase.
Selected Publications
Burrell M. R., Just V. J., Bowater L., Fairhurst S. A., Requena L., Lawson D. M., Bornemann S. (2007)
Oxalate decarboxylase and oxalate oxidase activities can be interchanged with a specificity switch of up to 282 000 by mutating an active site lid
Biochemistry 46 12327-12336
Just V. J., Burrell M. R., Bowater L., McRobbie I., Stevenson C. E. M., Lawson D. M., Bornemann S. (2007)
The identity of the active site of oxalate decarboxylase and the importance of the stability of active site lid conformations
Biochemical Journal 407 397-406
Recent Publications
Clé C., Martin C., Field R. A., Kuzmic P., Bornemann S. (2010)
Detection of enzyme-catalyzed polysaccharide synthesis on surfaces
Biocatalysis and Biotransformation 28 (1) 64-71
Rauch G., Ehammer H., Bornemann S., Macheroux P. (2008)
Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity
FEBS Journal 275 1464-1473