John Innes Centre

Prof Mark Buttner

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Curriculum Vitae

  • 1981 BSc, Biochemistry, University of Southampton, UK
  • 1985 PhD, Biochemistry, University of Bristol, UK
  • 1985 - 1988 Postdoctoral Fellow, John Innes Centre, UK
  • 1988 - 1990 SERC Postdoctoral Research Fellow, John Innes Centre, UK
  • 1990 - 1994 SERC Advanced Research Fellow, John Innes Centre, UK
  • 1994 - 1999 Lister Institute Research Fellow, John Innes Centre, UK
  • 1996 - 1999 Project Leader, Band 5, John Innes Centre, UK
  • 1999 - 2002 Project Leader, Band 4, John Innes Centre, UK
  • 2002 - present Project Leader, Band 3, John Innes Centre, UK
  • 2005 - present Honorary Professor, University of East Anglia, UK

Mark Buttner

Project Leader

Molecular Microbiology

Contact details

mark.buttner@bbsrc.ac.uk

Research interests

1. Control of differentiation in Streptomyces.

2. RNA polymerase and sigma factor function in Streptomyces.

3. Oxidative stress in Streptomyces.

4. Cell wall homeostasis in Streptomyces.

5. Vancomycin resistance in Streptomyces.

Recent Publications

Koteva K., Hong H. J., Wang X. D., Nazi I., Hughes D., Naldrett M. J., Buttner M. J., Wright G. D. (2010)
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.
Nature Chemical Biology 6 (5) 327-329
DOI:10.1038/nchembio.350
Crack J. C., den Hengst C. D., Jakimowicz P., Subramanian S., Johnson M. K., Buttner M. J., Thomson A. J., Le Brun N. E. (2009)
Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.
Biochemistry 48 (51) 12252-12264
DOI:10.1021/bi901498v
Edwards M. J., Flatman R. H., Mitchenall L. A., Stevenson C. E., Le T. B., Clarke T. A., McKay A. R., Fiedler H. P., Buttner M. J., Lawson D. M., Maxwell A. (2009)
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase
Science 326 (5958) 1415-8
DOI:10.1126/science.1179123
Flärdh K., Buttner M. J. (2009)
Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
Nature Reviews Microbiology 7 (1) 36-49
Le T. B., Fiedler H. P., den Hengst C. D., Ahn S. K., Maxwell A., Buttner M. J. (2009)
Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus.
Molecular Microbiology 72 (6) 1462-1474
DOI:10.1111/j.1365-2958.2009.06735.x
den Hengst C. D., Buttner M. J. (2008)
Redox control in actinobacteria
Biochimica et Biophysica Acta - General Subjects 1780 (11) 1201-1216
Di Berardo C., Capstick D. S., Bibb M. J., Findlay K. C., Buttner M. J., Elliot M. A. (2008)
Function and redundancy of the chaplin cell surface proteins in aerial hypha formation, rodlet assembly, and viability in Streptomyces coelicolor.
Journal of Bacteriology 190 (17) 5879-5889
DOI:10.1128/JB.00685-08
Elliot M. A., Buttner M. J., Nodwell J. R. (2008)
Multicellular development in Streptomyces
Myxobacteria: Multicellularity and Differentiation
ASM Press
(chapter unknown) 419-438
Hong H. J., Hutchings M. I., Buttner M. J. (2008)
Vancomycin resistance VanS/VanR two-component systems
Advances in Experimental Medicine and Biology: Bacterial Signal Transduction: Networks and Drug Targets
Landes Bioscience
631 (14) 200-213
Sello J. K., Buttner M. J. (2008)
The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target.
FEMS Microbiology Letters 286 60-65
DOI:10.1111/j.1574-6968.2008.01260.x