John Innes Centre

Prof Mark Buttner

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Curriculum Vitae

  • 1981 BSc, Biochemistry, University of Southampton, UK
  • 1985 PhD, Biochemistry, University of Bristol, UK
  • 1985 - 1988 Postdoctoral Fellow, John Innes Centre, UK
  • 1988 - 1990 SERC Postdoctoral Research Fellow, John Innes Centre, UK
  • 1990 - 1994 SERC Advanced Research Fellow, John Innes Centre, UK
  • 1994 - 1999 Lister Institute Research Fellow, John Innes Centre, UK
  • 1996 - 1999 Project Leader, Band 5, John Innes Centre, UK
  • 1999 - 2002 Project Leader, Band 4, John Innes Centre, UK
  • 2002 - present Project Leader, Band 3, John Innes Centre, UK
  • 2005 - present Honorary Professor, University of East Anglia, UK

Mark Buttner

Project Leader

Molecular Microbiology

Contact details

mark.buttner@jic.ac.uk

Research interests

1. Control of differentiation in Streptomyces.

2. RNA polymerase and sigma factor function in Streptomyces.

3. Oxidative stress in Streptomyces.

4. Cell wall homeostasis in Streptomyces.

5. Vancomycin resistance in Streptomyces.

Recent Publications

Crack J. C., Smith L. J., Stapleton M. R., Peck J., Watmough N. J., Buttner M. J., Buxton R. S., Green J., Oganesyan V. S., Thomson A. J., Le Brun N. E. (2011)
Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins
Journal of the American Chemical Society 133 (4) 1112-1121
DOI:10.1021/ja109581t
Le T. B., Schumacher M. A., Lawson D. M., Brennan R. G., Buttner M. J. (2011)
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.
Nucleic Acids Research 39 (21) 9433-9447
DOI:10.1093/nar/gkr640
Le T. B., Stevenson C. E., Fiedler H. P., Maxwell A., Lawson D. M., Buttner M. J. (2011)
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression
Journal of Molecular Biology 408 (1) 40-56
DOI:10.1016/j.jmb.2011.02.035
Le T., Stevenson C. E. M., Buttner M. J., Lawson D. M. (2011)
Crystallization and preliminary X-ray analysis of theTetR-like efflux pump regulator SimR
Acta Crystallographica Section F F67 307-309
Tran N. T., Den Hengst C. D., Gomez-Escribano J. P., Buttner M. J. (2011)
Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor
Journal of Bacteriology 193 (12) 3100-3108
DOI:10.1128/JB.01460-10
den Hengst C. D., Tran N. T., Bibb M. J., Chandra G., Leskiw B. K., Buttner M. J. (2010)
Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth
Molecular Microbiology 78 (2) 361–379
DOI:10.1111/j.1365-2958.2010.07338.x
Koteva K., Hong H. J., Wang X. D., Nazi I., Hughes D., Naldrett M. J., Buttner M. J., Wright G. D. (2010)
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.
Nature Chemical Biology 6 (5) 327-329
DOI:10.1038/nchembio.350