Jo Dicks
Project Leader
Computational and Systems Biology
Contact details
jo.dicks@jic.ac.uk
Research interests
MET ISP
With the Osbourn group we are discovering genetic and genomic features of functional plant gene clusters, to more fully understand the evolutionary processes driving their creation. In addition, we are beginning to use machine learning techniques that use these features to hunt for candidate gene clusters in newly-sequenced plant genomes.
With the O'Maille group we are developing new computational methodologies to reconstruct catalytic landscapes from partial SCOPE analyses. Path analyses on the reconstructed landscapes then enable us to understand potential evolutionary trajectories of enzyme sequences.
DEV ISP
With the Ellis group we have developed a new approach to genetic mapping, THREaD Mapper. The software enables the estimation of visual, global genetic maps that may be integrated visually with genomic sequence. In collaboration with the Snape, Griffiths and Bancroft groups we are pushing THREaD Mapper's analytical capabilities, most recently for high-throughput genetic mapping datasets consisting of tens of thousands of markers.
With the Griffiths group we are developing further our Tyrant software to analyse the genetic diversity of a key wheat germplasm collection.
We lead the JIC effort within the BBSRC MONOGRAM Informatics Working Group, working closely with bioinformaticians at RRes, IBERS and SCRI. Our aim is to optimise the flow of information, expertise, data and tools throughout the BBSRC and UK crop plant communities.
Selected Publications
Etherington G. J., Dicks J., Roberts I. N. (2005)
Recombination analysis tool (RAT): a program for the high-throughput detection of recombination
Bioinformatics 21 278-281
Lee J. M., Davenport G. F., Marshall D., Ellis T. H. N., Ambrose M. J., Dicks J., van Hintum T. J. L., Flavell A. J. (2005)
GERMINATE. A generic database for integrating genotypic and phenotypic information for plant genetic resource collections
Plant Physiology 139 619-631
Recent Publications
Inagaki Y. S., Etherington G., Geisler K., Field B., Dokarry M., Ikeda K., Mutsukado Y., Dicks J., Osbourn A. (2011)
Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering
New Phytologist 191 (2) 432-448
Davey R. P., James S. A., Dicks J., Roberts I. N. (2010)
TURNIP: Tracking unresolved nucleotide polymorphisms in large hard-to-assemble regions of repetitive DNA sequence
Bioinformatics 26 (22) 2908-2909
Garvin D. F., McKenzie N., Vogel J. P., Mockler T. C., Blankenheim Z. J., Wright J., Cheema J. J. S., Dicks J., Huo N., Hayden D. M., Gu Y., Tobias C., Chang J. H., Chu A., Trick M., Michael T. P., Bevan M. W., Snape J. W. (2010)
An SSR-based genetic linkage map of the model grass Brachypodium distachyonGenome
53 (1) 1-13
DOI:10.1139/G09-079