John Innes Centre

Dr Claire Domoney

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Curriculum Vitae

  • 1976 BSc, University College, Dublin
  • 1977 Higher Diploma in Education, University College, Dublin
  • 1978 MSc, University College, Dublin
  • 1982 PhD, University of East Anglia
  • 1982 Post-doctoral fellow, John Innes Centre
  • 1997 Project Leader, Department of Applied Genetics, John Innes Centre
  • 2001 Project Leader, Department of Metabolic Biology, John Innes Centre

Claire Domoney

Project Leader

Metabolic Biology

Contact details

Tel: +44 (0)1603 450381
claire.domoney@jic.ac.uk

Research interests

The focus of the laboratory is on defining and understanding the genetic and biochemical control of legume seed composition and nitrogen accumulation, which are relevant both to food/feed end use and to the development of improved crops that promote sustainable agriculture. In pea, metabolite analysis is being used to identify the pleiotropic effects of mutations in protease inhibitors and other regulatory proteins, where functions have not been defined. Variation in genes encoding enzymes of senescence-related processes is being studied for its significance to nitrogen reassimilation, and relevance to crop end use.  Dissecting the function of individual genes exploits both natural variation and mutants isolated by TILLING. We are also interested in the effects of plant stress, to understand the impact of drought stress on the metabolome of seeds in particular.

We have forged strong links with end users through the Pulse Crop Genetic Improvement Network and an industrially-linked project, Understanding Quality Determinants in Pea Seeds to improve market opportunities that promote sustainable agriculture (QDiPS: drivers of a sustainable agriculture). (http://www.pcgin.org/)

Selected Publications

Charlton A. J., Donarski J. A., Harrison M., Jones S. A., Godward J., Oehlschlager S., Arques J. L., Ambrose M., Chinoy C., Mullineaux P. M., Domoney C. (2008)
Responses of the pea (Pisum sativum L.) leaf metabolome to drought stress assessed by nuclear magnetic resonance spectroscopy
Metabolomics 4 (4) 312-327
DOI:10.1007/s11306-008-0128-0
Vigeolas H., Chinoy C., Zuther E., Blessington B., Geigenberger P., Domoney C. (2008)
Combined metabolomic and genetic approaches reveal a link between the polyamine pathway and albumin 2 in developing pea seeds.
Plant Physiology 146 (1) 74-82
DOI:10.1104/pp.107.111369

Recent Publications

Chinoy C., Welham T., Turner L., Moreau C., Domoney C. (2011)
The genetic control of seed quality traits: effects of allelic variation at the Tri and Vc-2 genetic loci in Pisum sativum L.
Euphytica 180 (1 Sp. Iss. S1) 107-122
DOI:10.1007/s10681-011-0363-8
Clemente A., Marin-Manzano M. C., Domoney C. (2011)
Exploiting natural variation in legume Bowman-Birk inhibitors to dissect their potential role in human health-promoting programmes
Canadian Journal of Plant Science 91 377-378
Clemente A., Sonnante G., Domoney C. (2011)
Bowman-Birk inhibitors from legumes and human gastrointestinal health: current status and perspectives.
Current Protein & Peptide Science 12 358-373
Clemente A., Moreno F. J., Marin-Manzano M. C., Jimenez E., Domoney C. (2010)
The cytotoxic effect of Bowman-Birk isoinhibitors, IBB1 and IBBD2, from soybean (Glycine max) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases.
Molecular Nutrition and Food Research 54 396-405
DOI:10.1002/mnfr.200900122