Group Leader
Related links
- AT JIC:
- Biological Chemistry
- ON THE WEB:
- protein information database
- Search PUBMED
Curriculum Vitae
- 1994 BSc (Hons), University of Newcastle, Australia
- 1995-1996 Research Assistant, University of Sydney, Australia
- 2001 PhD, University of Queensland, Brisbane, Australia
- 2000-2008 Postdoctoral Research Associate, University of Oregon, USA
- 2008 Marie Curie Incoming International Fellow
- 2008-present Project Leader, John Innes Centre, UK
Sandra Greive
Post Doctoral Scientist
Biological Chemistry
Contact details
Research interests
Biology makes use of switches to finely regulate the processes required for life, including the elongation phase of the RNA transcription process. The elongation complex formed after conversion from the initiation complex proximal to the promoter sequence can be kinetically regulated by signals in the nascent RNA and template DNA and by protein co-factors that may bind to these signals, promoting or preventing transcriptional termination, acting as one of many switches controlling the gene expression process. Sandra Greive uses a range of biochemical and biophysical techniques to dissect the molecular mechanisms of the switches that act during the elongation phase of RNA transcription. Knowledge of the interactions that form the protein-nucleic acid complexes required for regulating these transcription elongation switches and how the elongation complex responds to them will contribute to our understanding of how cells rapidly and specifically alter their gene expression in response to environmental signals.
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