John Innes Centre

Prof George Lomonossoff

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Curriculum Vitae

  • 1979 Post-doctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge
  • 1980 PhD, University of Cambridge
  • 1980 Higher Scientific Officer, JIC
  • 1984 Senior Scientific Officer, JIC
  • 1987 Fulbright Scholar, Cornell University, USA
  • 1990 Project Leader, JIC
  • 1998 Visiting Investigator, The Scripps Research Institute, La Jolla, USA
  • 1998-present Honorary Reader, University of East Anglia

George Lomonossoff

Project Leader

Biological Chemistry

Contact details

george.lomonossoff@jic.ac.uk

Research interests

  • The specificity of protein-protein and protein-RNA interactions in the morphogenesis of virus structures
  • The modification of virus particles and the uses of such particles in biotechnology
  • The development of RNA plant virus-based vectors and their application for expression of high-value proteins of pharmaceutical interest in plants

    • Selected Publications

    Aljabali A. A. A., Sainsbury F., Lomonossoff G., Evans D. J. (2010)
    Cowpea mosaic virus unmodified empty viruslike particles can be loaded with metal and metal oxide.
    Small 6 (7) 818-821
    DOI:10.1002/smll.200902135
    Sainsbury F., Lomonossoff G. P. (2008)
    Extremely high-level and rapid transient protein production in plants without the use of viral replication
    Plant Physiology 148 (3) 1212-1218
    DOI:10.1104/pp.108.126284
    Steinmetz N. F., Lin T., Lomonossoff G. P., Johnson J. E. (2008)
    Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology
    Current Topics of Microbiology and Immunology
    Springer
    327 (2) 23-58

    Recent Publications

    Vardakou M., Sainsbury F., Rigby N., Mulholland F., Lomonossoff G. P. (2012)
    Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system
    Protein Expression and Purification 81 (1) 69-74
    DOI:10.1016/j.pep.2011.09.005
    Aljabali A. A. A., Barclay J. E., Cespedes O., Rashid A., Staniland S. S., Lomonossoff G. P., Evans D. J. (2011)
    Charge modified Cowpea mosaic virus particles for templated mineralization
    Advanced Functional Materials 21 (21) 4137-4142
    Aljabali A. A. A., Lomonossoff G. P., Evans D. J. (2011)
    CPMV-polyelectrolyte-templated gold nanoparticles
    Biomacromolecules 12 (7) 2723-2728
    Aljabali A. A. A., Shah S. N., Evans-Gowing R., Lomonossoff G. P., Evans D. J. (2011)
    Chemically-coupled-peptide promoted virus nanoparticle templated mineralization.
    Integrative Biology 3 (2) 119-125
    DOI:10.1039/COIB00056F
    Montague N. P., Thuenemann E. C., Saxena P., Saunders K., Lenzi P., Lomonossoff G. P. (2011)
    Recent advances of Cowpea mosaic virus-based particle technology.
    Human Vaccine 7 (3) 383-90
    Sainsbury F., Saunders K., Aljabali A. A. A., Evans D. J., Lomonossoff G. P. (2011)
    Peptide-controlled access to the interior surface of empty virus nanoparticles
    ChemBioChem 12 (16) 2435-2440
    Saxena P., Hsieh Y. C., Alvarado V. Y., Sainsbury F., Saunders K., Lomonossoff G. P., Scholthof H. B. (2011)
    Improved foreign gene expression in plants using a virus-encoded suppressor of RNA silencing modified to be developmentally harmless.
    Plant Biotechnology Journal 9 (6) 703-12
    DOI:10.1111/j.1467-7652.2010.00574.x
    Sohn S. H., Choi M. S., Kim K. H., Lomonossoff G. (2011)
    The epigenetic phenotypes in transgenic Nicotiana benthamiana for CaMV 35S-GFP are mediated by spontaneous transgene silencing
    Plant Biotechnology Reports 5 273-281
    DOI:10.1007/s11816-011-0182-3
    Sohn S. H., Huh S. M., Kim K. H., Park J. W., Lomonossoff G. (2011)
    Effect of Rice Stripe virus NS3 on transient gene expression and transgene co-silencing
    Plant Pathology Journal (Korea) 27 (4) 310-314
    Sun Q. Y., Ding L. W., Lomonossoff G. P., Sun Y. B., Luo M., Li C. Q., Jiang L., Xu Z. F. (2011)
    Improved expression and purification of recombinant human serum albumin from transgenic tobacco suspension culture.
    Journal of Biotechnology 155 (2) 164-72
    DOI:10.1016/j.jbiotec.2011.06.033
    Aljabali A. A. A., Barclay J. E., Butt J. N., Lomonossoff G. P., Evans D. J. (2010)
    Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles.
    Dalton Transactions 39 (32) 7569-7574
    Aljabali A. A. A., Barclay J. E., Lomonossoff G. P., Evans D. J. (2010)
    Virus templated metallic nanoparticles
    Nanoscale 2 (12) 2596-2600