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Nikolai Adamski and Michael Lenhard Nikolai Adamski and Michael Lenhard


Key seed size gene identified

5th November 2009

Scientists from the John Innes Centre in Norwich, UK and the University of Freiburg in Germany have uncovered a gene in plants that is responsible for controlling the size of seeds, which could lead to ways of improving crops to help ensure food security in the future.

Increasing seed or grain size has been key in the domestication of the crops used in modern agriculture, and with a growing world population, further increasing the yield of crops is one goal of agricultural research.  Michael Lenhard, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), has identified a gene in the model plant Arabidopsis that determines overall seed size, and is now investigating how this could be used to for the improvement of crops.

Publishing in the Proceedings of the National Academy of Sciences, the team from the John Innes Centre, an institute of the BBSRC, demonstrated that the gene acts locally at the base of the growing seed.  It produces an as yet unidentified mobile growth signal that determines final seed size.   If the gene is turned off, smaller seeds are produced, but crucially if the gene is turned on at a higher level than normal, seeds a third larger in size and weight are produced.  This is the first time such a reciprocal effect on seed size has been observed, and points to the fundamental importance of this gene in plant development.

More work is now needed before this research can be applied to crop plants.  One effect of increasing the seed size in the experimental plants was to decrease the total number of seeds produced, so there was no overall increase in yield.  The scientists did notice an increase in the relative oil content of the larger seeds, so the effects of altering this gene in oil seed rape is currently being investigated.
Unravelling this gene’s role in determining the final seed size will also be important for other strategies for increasing yield, an example of how fundamental plant science can inform and drive efforts to ensure food security. 

Professor Mike Bevan, Acting Director of the John Innes Centre, said “This work shows how JIC's focus on understanding the mechanisms controlling plant growth can have immediate useful application for crop improvement.”


JIC Press Office:

Andrew Chapple, Tel: 01603 251490, email:
Zoe Dunford, Tel: 01603 255111, email:

Notes to Editors:

Reference: Local maternal control of seed size by KLUH/CYP78A5-dependent growth
Signalling, PNAS,Published online before print November 5, 2009,
doi: 10.1073/pnas.0907024106

Funding:  BBSRC David Phillips Fellowship

About the JIC

The John Innes Centre,, is an independent, world-leading research centre in plant and microbial sciences with over 800 staff. JIC is based on Norwich Research Park and carries out high quality fundamental, strategic and applied research to understand how plants and microbes work at the molecular, cellular and genetic levels. The JIC also trains scientists and students, collaborates with many other research laboratories and communicates its science to end-users and the general public. The JIC is grant-aided by the Biotechnology and Biological Sciences Research Council.  


The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest in universities, centres and institutes.

The Babraham Institute, Institute for Animal Health, Institute of Food Research, John Innes Centre and Rothamsted Research are Institutes of BBSRC. The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.