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an antibiotic molecule bound to a topoisomerase
An antibiotic molecule bound to a topoisomerase

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DNA Topoisomerases in Biology and Medicine

July 2008

International scientists working on new drug discovery targets for cancer and bacterial diseases are meeting in Norwich next week to share their latest findings. 

"The meeting presents exciting new opportunities for scientific collaborations and helps to establish Norwich as one of the top places for scientific research in the UK,” says meeting co-organiser Prof. Tony Maxwell. 

The scientists attending Topo2008 all work in the field of topoisomerases, enzymes that act on the double strands of DNA to stop them becoming tangled. Without topoisomerases, cells die as they replicate. One way of stopping diseased cells from growing is to inhibit topoisomerases, for example to stop the uncontrolled cell division characteristic of cancer.

As well as sharing fundamental research findings, the scientists will showcase how their work is being translated into the discovery of new drugs.

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 Contacts:

JIC Press Office
Zoe Dunford, Tel: 01603 255111, email: zoe.dunford@jic.ac.uk
Andrew Chapple, Tel: 01603 251490, email: andrew.chapple@jic.ac.uk

 Notes for Editors: 

  • The John Innes Centre, www.jic.ac.uk, is an independent, world-leading research centre in plant and microbial sciences with over 800 staff. JIC is based on Norwich Research Park and carries out high quality fundamental, strategic and applied research to understand how plants and microbes work at the molecular, cellular and genetic levels. The JIC also trains scientists and students, collaborates with many other research laboratories and communicates its science to end-users and the general public. The JIC is grant-aided by the Biotechnology and Biological Sciences Research Council.  
  • Inspiralis www.inspiralis.com, based at the Norwich Bio-Incubator at JIC, supplies topoisomerases and other products and services to the pharmaceutical industry and academia to aid in research to discover new anti-infective and anti-cancer drugs and to investigate how these important proteins function. It also provides screening services to the pharmaceutical industry to test potential drugs against topoisomerases. The company uses a high-throughput assay developed in the laboratory of Professor Maxwell and patented by Plant Biosciences Limited.