Dr. Tobias Kieser,

Curriculum vitae

Diploma (equiv. Masters): Biochemistry, ETH Zurich, Switzerland (1974)
Dr. Sc. Natw. (equiv. PhD): Microbiology, ETH Zurich, 1979
Postdoc:  John Innes Centre, Norwich, UK (1979-1988)
Research Scientist and Honorary Lecturer UEA, Norwich, UK (1988- present)
 

Research Interests

Functional Streptomyces ceolicolor genomics using large-scale transposon mutagenesis

Functioning of Streptomyces transposable elements in M. smegmatis.

Natural competence of M. smegmatis.
 

Group members

Kay Fowler
 

Recent publications

Sun Y, Zhou X, Liu J, Bao K, Zhang G, Tu G, Kieser T, Deng Z.  'Streptomyces nanchangensis', a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide  meilingmycin, contains multiple polyketide gene clusters.  Microbiology. 2002 Feb;148(Pt 2):361-71

Apoorva M. Bhatt, Graham. R. Stewart, Douglas B. Young, and Tobias Kieser.  Transposition of Tn4560 of Streptomyces fradiae in mycobacteria.  FEMS Microbiol Lett. 2002 Jan 10;206(2):241-6

Apoorva M. Bhatt, Helen M. Kieser, Rachel E. Melton, and Tobias Kieser.  Plasmid transfer from Streptomyces to Mycobacterium smegmatis by spontaneous transformation. Mol Microbiol. 2002 Jan;43(1):135-46.

B.J.F. Keijser, G.P. van Wezel, G.W. Canters, T.Kieser, and E. Vijgenboom (2000).  The ram-dependence of Streptomyces lividans differentiation is bypassed by copper. J Mol Microbiol Biotechnol 2(4): 565-574.

Tao MF, Hu ZH, Zhou XF, Zhou Q, Deng ZX, Kieser T, Hopwood DA.(1999)  Over- expression of a polyketide synthase (PKS) module of a giant polyene antibiotic gene cluster in E. coli by double induction. Yi Chuan Xue Bao. 26(6):721-30.

Kieser T, Bibb M J, Buttner M J, Chater K F and Hopwood D A (1999). Practical Streptomyces genetics. John Innes Foundation.

Bhatt, A. and Kieser, T.  (1999) Transposition of IS117 of Streptomyces coelicolor A3(2) in Mycobacterium smegmatis.  Microbiology 145, 1201-7.

Jacobs WR Jr, Barletta RG, Udani R, Chan J, Kalkut G, Sosne G, Kieser T, Sarkis GJ, Hatfull GF, Bloom BR. (1993) Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science260:819-22.

Snapper SB, Melton RE, Mustafa S, Kieser T, Jacobs WR Jr. (1990)  Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis.  Mol Microbiol 4:1911-9.

Jacobs WR Jr, Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR (1989) Development of genetic systems for the mycobacteria. Acta Leprol 7 Suppl 1:203-7.

Hopwood DA, Kieser T, Colston MJ, Lamb FI. (1988)  Molecular biology of mycobacteria.  Br Med Bull 44(3):528-46.

Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR, Jacobs WR Jr.(1988)  Lysogeny and transformation in mycobacteria: stable expression of foreign genes.  Proc Natl Acad Sci USA85(18):6987-91.
 
 
 

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