Mark Buttner's Publications

Mark Buttner

Recent publications

Crack, J.C., den Hengst, C.D., Jakimowicz, P., Subramanian, S., Johnson, M.K., Buttner, M.J., Thomson, A.J. and Le Brun, N.E. (2009) Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD. Biochemistry 48: (51) 12252-12264. Download as PDF

Edwards, M., Flatman, R., Mitchenall, L., Stevenson, C., Le, T., Clarke, T., McKay, A., Fiedler, H-P., Buttner, M., Lawson, D. and Maxwell, A. (2009) A crystal structure of the bifunctional antibiotic, simocyclinone D8, bound to DNA gyrase. Science 326:(5958) 1415-1418. Download as PDF

Le, T.B, Fiedler, H.P., den Hengst, C.D., Ahn, S.K., Maxwell, A. and Buttner, M.J. (2009) Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus. Mol Microbiol. 72: 1462-1474. Download as PDF

Flärdh, K., and Buttner, M.J. (2009) Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium. Nat. Rev. Microbiol. 7: 36-49. Download as PDF

den Hengst, C.D. and Buttner, M.J. (2008) Redox control in actinobacteria. Biochim Biophys Acta. 1780: 1201-1216. Download as PDF

Di Berardo, C., Capstick, D.S., Bibb, M.J., Findlay, K.C., Buttner, M.J. and Elliot, M.A. (2008) Function and redundancy of the chaplin cell surface proteins in aerial hypha formation, rodlet assembly, and viability in Streptomyces coelicolor. J Bacteriol. 190: 5879-5889. Download as PDF

Sello, J. K. and Buttner, M. J. (2008) The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target. FEMS Microbiol Lett. 286: 60-65. Download as PDF

Sello, J. K. and Buttner, M. J. (2008) The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation. J Bacteriol. 190: 4079-4083. Download as PDF

Hong, H.-J., Hutchings, M. I., and Buttner, M. J. (2008) Vancomycin resistance VanRS two-component systems. In: Bacterial Signal Transduction: Networks and Drug Targets (Utsumi, R., ed). Landes Bioscience, pp 200-213 ISBN 978-0-387-78884-5. Download as PDF

Ausmees, N., Wahlstedt, H., Bogchi, S., Elliot, M. A., Buttner, M. J., Flärdh, K. (2007) SmeA, a small membrane protein with multiple functions in Streptomyces sporulation including targeting of a SpoIIIE/FtsK-like protein to cell division septa. Mol. Microbiol. 65: 1458-1473. Download as PDF

Elliot, M. A., Buttner, M. J., Nodwell, J. R. (2007) Multicellular development in Streptomyces. In: Myxobacteria: Multicellularity and Differentiation (Whitworth, D. E., ed). American Society for Microbiology Press, pp 419-438. ISBN 978-1-55581-420-5. Download as PDF

Capstick, D.S., Willey, J.M., Buttner, M.J., and Elliot, M.A. (2007) SapB and the chaplins: Connections between morphogenetic proteins in Streptomyces coelicolor. Mol. Microbiol. 64: 602-613. Download as PDF

Hutchings, M.I., Hong, H.-J., Leibovitz, E., Sutcliffe, I.C., and Buttner M.J. (2006) The σE cell envelope stress response of Streptomyces coelicolor is influenced by a novel lipoprotein, CseA. J. Bacteriol. 188: 7222-7229. Download as PDF

Zdanowski, K., Doughty, P., Jakimowicz, P., O’ Hara, L., Buttner, M.J., Paget, M.S.B., and Kleanthous, C. (2006) Assignment of the zinc ligands in RsrA, a redox-sensing ZAS protein from Streptomyces coelicolor . Biochemistry 45: 8294-8300. Download as PDF

Hoskisson, P.A., Rigali, S., Fowler, K., Findlay, K.C., and Buttner, M.J. (2006) DevA, a GntR-like transcriptional regulator required for development in Streptomyces coelicolor. J. Bacteriol. 188: 5014-5023. Download as PDF

Tello, M., Jakimowicz, P., Errey, J.C., Freel Meyers, C.L., Walsh, C.T., Buttner, M.J., Lawson, D.M., and Field, R.A. (2006) Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chem. Comm. 2006: 1079-1081. Download as PDF

Jakimowicz, P., Tello, M., Freel-Meyers, C.L., Walsh, C.T., Buttner, M.J., Field, R.A., and Lawson, D.M. (2006) The 1.6 Å resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides. Proteins: Structure, function and bioinformatics. 63: 261-265. Download as PDF

Hutchings, M. I., Hong, H-J. and Buttner, M.J. (2006). The vancomycin resistance VanRS signal transduction system of Streptomyces coelicolor. Mol. Microbiol. 59: 923-935. Download as PDF

Huang, J., Shi, J., Molle, V., Sohlberg, B., Weaver, D., Bibb, M. J., Karoonuthaisiri, N., Lih, C.-J., Kao, C. M., Buttner, M. J. and Cohen, S. N. (2005) Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol. Microbiol. 58: 1276-1287. Download as PDF

Hong, H-J.; Hutchings, M.I.; Hill, L. and Buttner, M.J. (2005) The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. J Biol Chem. 280: 13055–13061. Download as PDF

Jakimowicz,P.; Cheesman,M.R.; Bishai,W.R.; Chater,K.F.; Thomson,A.J. and Buttner, M.J. (2005) Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster. J. Biol. Chem. 280; 8309-15. Download as PDF

Hunt, A.C.; Servin-Gonzalez, L.; Kelemen, G.H. and Buttner, M.J. (2005) The bldC Developmental Locus of Streptomyces coelicolor Encodes a Member of a Family of Small DNA-Binding Proteins Related to the DNA-Binding Domains of the MerR Family. J.Bacteriol. 187:2, 716-728. Download as PDF

Elliot, M. A. and Talbot, N. J. (2004). Building filaments in the air: aerial morphogenesis in bacteria and fungi. Curr Opin Microbiol. 7: 594-601. Download as PDF

Tyers, M. and Buttner, M.J. (2004) Growth and development The whole picture begins to emerge. Curr. Opin. Microbiol. 7: 561-564. Download as PDF

Hutchings, M.I.; Hoskisson, P.A.; Chandra, G. and Buttner, M.J. (2004) Sensing and responding to diverse extracellular signals? Analysis of the sensor kinases and response regulators of Streptomyces coelicolor A3(2). Microbiology 150: 2795-2806. Download as PDF

Kodani, S.; Hudson, M.E.; Durrant, M.C.; Buttner, M.J.; Nodwell, J.R.; Willey, J.M. (2004) The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc. Natl. Acad. Sci.U.S.A. 101 (31): 11448-11453. Download as PDF

Hong, H.J.; Hutchings, M.I.; Neu, J.M.; Wright, G.D.; Paget, M.S. and Buttner, M.J. (2004) Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. Mol.Microbiol. 52: 1107-1121. Download as PDF

Paget, M.S. and Buttner, M.J. (2003) Thiol-based regulatory switches. Annu. Rev. Genet. 37: 91-121. Download as PDF

Li, W.; Bottrill, A.R.; Bibb, M.J.; Buttner, M.J.; Paget, M.S. and Kleanthous, C. (2003) The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor. J.Mol.Biol. 333: 461-472.Download as PDF

Takano, E.; Tao, M.; Long, F.; Bibb, M.J.; Wang, L.; Li, W.; Buttner, M.J.; Bibb, M.J.; Deng, Z.X. and Chater, K.F. (2003) A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor. Mol.Microbiol. 50: 475-486. Download as PDF

Jakimowicz, P.; Freel Meyers, C.L.; Walsh, C.T.; Buttner, M.J. and Lawson, D.M. (2003) Crystallization and preliminary X-ray studies on the putative dTDP sugar epimerase NovW from the novobiocin biosynthetic cluster of Streptomyces spheroides. Acta Crystallogr.D.Biol.Crystallogr. D59: 1507-1509. Download as PDF

Elliot, M.A.; Karoonuthaisiri, N.; Huang, J.; Bibb, M.J.; Cohen, S.N.; Kao, C.M. and Buttner, M.J. (2003) The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor. Genes Dev. 17: 1727-1740. Download as PDF

Bibb, M.J; Buttner, M.J. (2003) The Streptomyces coelicolor developmental transcription factor sigmaBldN is synthesized as a proprotein. J.Bacteriol. 185 (7): 2338-2345. Download as PDF

Viollier P.H., Kelemen G.H., Dale G.E., Nguyen K.T., Buttner M.J. and Thompson C.J. (2003) Specialized osmotic stress response systems involve mutliple SigB-like sigma factors in Streptomyces coelicolor. Mol.Microbiol. 47(3): 699-714. Download as PDF

Hong H.J., Paget M.S.B., Hutchings M.I., Leibovitz E., and Buttner M.J. (2002) Sensing and responding to cell envelope stress in Streptomyces coelicolor. Actinomycetol. 16: 41-47.

Wei Li, Stevenson, C.E.M., Burton N., Jakimowicz P., Paget, M.S.B., Buttner M.J., Lawson D.M. and Kleanthous C. (2002) Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor sigma-R from Streptomyces coelicolor. J. Mol. Biol. 323: 225-236. Download as PDF

Hong, H.-J., Paget, M.S.B., and Buttner, M.J. (2002) A signal transduction system in Streptomyces coelicolor that activates the expression of a putative cell wall glycan operon in response to vancomycin and other cell wall-specific antibiotics. Mol. Microbiol. 44: 1199-1211. Download as PDF

Paget, M.S.B., Hong, H.-J., Bibb, M.J., and Buttner, M.J. (2002) The ECF sigma factors of Streptomyces coelicolor A3(2). In, Signals, Switches, Regulons and Cascades: Control of Bacterial Gene Expression. Hodgson, D.A. and Thomas, C.M. (eds). Cambridge University Press, pp 105-125. Download as PDF

Paget, M.S.B., Molle, V., Cohen, G., Aharonowitz, Y., and Buttner, M.J. (2001) Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigma-R regulon. Mol. Microbiol. 42: 1007-1020.

Kelemen, G.H., Viollier, P.H., Tenor, J., Marri, L., Buttner, M.J., and Thompson, C.J. (2001) A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2). Mol. Microbiol. 40: 804-814.

Elliot, M.A., Bibb, M.J., Buttner, M.J., and Leskiw, B.K. (2001) BldD is a direct regulator of key developmental genes in Streptomyces coelicolor A3(2). Mol. Microbiol. 40: 257-269.

Paget, M.S.B., Bae, J.-B., Hahn, M.-Y., Li, W., Kleanthous, C., Roe, J.-H., and Buttner, M.J. (2001) Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch. Mol. Microbiol. 39: 1036-1047.

Flärdh, K., Leibovitz, E., Buttner, M.J., and Chater, K.F. (2000) Generation of a non-sporulating strain of Streptomyces coelicolor A3(2) by the manipulation of a developmentally controlled ftsZ promoter. Mol. Microbiol. 38: 737-749.

Bibb, M.J., Molle, V., and Buttner, M.J. (2000) Sigma BldN, an extracytoplasmic function RNA polymerase sigma factor required for aerial mycelium formation in Streptomyces coelicolor A3(2). J. Bacteriol. 182: 4606-4616.

Burger, A., Sichler, K., Kelemen, G., Buttner, M.J., and Wohlleben, W. (2000) Identification and characterization of the mre gene region of S. coelicolor A3(2). Mol. Gen. Genet. 263: 1053-1060.

Kieser, T, Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces Genetics. Norwich: The John Innes Foundation.

Molle, V., and Buttner, M.J. (2000) Different alleles of the response regulator gene bldM arrest Streptomyces coelicolor development at distinct stages. Mol. Microbiol. 36: 1265-1278.

Molle, V., Palframan, W.J., Findlay, K.C., and Buttner, M.J. (2000) WhiD and WhiB, homologous proteins required for different stages of sporulation in Streptomyces coelicolor A3(2). J. Bacteriol. 182: 1286-1295.

Paget, M.S.B., Leibovitz, E., and Buttner, M.J. (1999) A putative two-component signal transduction system regulates sigmaE, a sigma factor required for normal cell wall integrity in Streptomyces coelicolor A3(2). Mol Microbiol 33: 97-107.

Kang, J.-G., Paget, M.S.B., Seok, Y.-J., Hahn, M.-Y., Bae,J.-B., Hahn, J.-S., Kleanthous, C., Buttner, M.J., and Roe, J.-H. (1999) RsrA, an anti-sigma factor regulated by redox change. EMBO J. 18: 4292-4298.

Ryding, N.J., Bibb, M.J., Molle, V., Findlay, K.C., Chater, K.F., and Buttner, M.J. (1999) New sporulation loci in Streptomyces coelicolor A3(2). J. Bacteriol 181: 5419-5425.

Paget, M.S.B., Chamberlin, L., Atrih, A., Foster, S.J., and Buttner, M.J. (1999) Evidence that the extracytoplasmic sigma factor, sigmaE, is required for normal cell wall structure in Streptomyces coelicolor A3(2). J. Bacteriol 181: 204-211.

Georgiou, T., Yu, Y.-T.N., Ekunwe, S., Buttner, M.J., Zuurmond, A.-M., Kraal., B., Kleanthous, C., and Snyder, L. (1998) Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu. Proc. Natl. Acad. Sci. USA 95: 2891-2895.

Kelemen, G.H., Brian, P., Flärdh, K., Chamberlin, L., Chater ,K.F., and Buttner, M.J. (1998) Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3(2). J. Bacteriol 180: 2515-2521.

Tan, H., Yang, H., Tian, Y., Wu, W., Whatling, C.A., Chamberlin, L.C., Buttner, M.J., Nodwell, J., and Chater, K.F. (1998) The Streptomyces coelicolor sporulation-specific sigmaWhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensible for sporulation. Gene 212: 137-146.

Ryding N.J., Kelemen, G.H., Whatling, C.A., Flärdh, K., Buttner, M.J., and Chater, K.F. (1998) A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3(2) . Molecular Microbiology29: 343-357.

Paget, M.S.B., Kang, J.-G., Roe, J.-H., and Buttner, M.J. (1998) SigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2) . EMBO Journal 17: 5776-5782.

Kelemen, G.H., and Buttner, M.J. (1998) Initiation of aerial mycelium formation in Streptomyces. Current Opinion in Microbiology 1: 656-662.