David Hopwood
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PublicationsHopwood D. A. (2009) (Editor) Complex enzymes in microbial natural product biosynthesis, part A and part B. Methods in Enzymology, Academic Press. Rigali, S., Titgemeyer, F., Barends, S., Mulder, S., Thomae, A. W., Hopwood, D. A., van Wezel, G. P. (2008) Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO reports 9: 670-675. Streptomyces in Nature and Medicine: The Antibiotic Makers (2007). New York, Oxford University Press. Hopwood, D. A. (2007) How do antibiotic-producing bacteria ensure their self-resistance before antibiotic biosynthesis incapacitates them? Mol. Microbiol 63: 937-940. Hopwood, D. A. (2007) Therapeutic treasures from the deep. Nature Chemical Biology 3: 457-458. Andor, A., Jeckel, A., Hopwood, D. A., Jeanplong, F., Ilkoy, A., Konya, I., Kuresz, I, Ambrus G. (2006) Generation of useful insertionally blocked sterol degradation pathway mutants in fast-growing mycobacteria and cloning, characterization, and expression of the terminal oxygenase of the 3-ketosteroid 9α-hydroxylase in Mycobacterium smegmatis mc2155. Appl. Env. Microbiol. 72: 6554-6559. Rigali, S., Nothaft, H., Noens., Schlicht, M., Colson, S., Müller, M., Joris, B., Koerten, H. K., Hopwood, D. A., Titgemeyer, F., van Wezel, G. P. (2006) The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development. Mol Microbiol 61: 1237-1251. Hopwood, D. A. (2006) Soil to genomics: the Streptomyces chromosome. Ann Rev Microbiol 40: 1-23. Van Keulen, G., Hopwood, D. A., Dijkhuizen, L, Sawers, R. G. (2005) Gas vesicles in actinomycetes: old buoys in novel habitats? Trends Microbiol 13: 350-354. Menzella, H. G., Reid, R., Carney, J. R., Chandran, S. S., Reisinger, S. J., Patel, K.G., Hopwood, D. A., Santi, D. (2005) Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nature Biotechnology 23: 1171-1176. Booker-Milburn K. I., Gillan R., Kimberley M., Taguchi T., Ichinose K., Stephenson G. R., Ebizuka Y., Hopwood D. A. (2005). Enantioselective Reduction of beta-Keto Acids with Engineered Streptomyces coelicolor. Angew Chem Int Ed Engl. 44: 1121-1125. Bentley, S. D., Gordon, S. V., Hopwood, D. A., Cole, S. T. (2004) Genomics of actinobacteria, the high G+C Gram-positive bacteria. In: Microbial Genomes (eds. C. M. Fraser, T. D. Read, K. E. Nelson). Humana Press, Totowa, NJ, pp. 333-359. Hopwood, D. A. (2004). Cracking the polyketide code. PLoS Biol. 2: E35. Weaver D., Karoonuthaisiri N., Tsai H. H., Huang C. H., Ho M. L., Gai S., Patel K. G., Huang J., Cohen S. N., Hopwood D. A., Chen C. W., Kao C. M. (2004). Genome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome. Mol Microbiol. 51: 1535-50. Hopwood, D. A. (2003). Streptomyces genes: from Waksman to Sanger. J Ind Microbiol Biotechnol. 30: 468-71. Hu Z., Hopwood D. A., Hutchinson C. R. (2003). Enhanced heterologous polyketide production in Streptomyces by exploiting plasmid co-integration. J Ind Microbiol Biotechnol. 30: 516-22. Challis G. L., Hopwood D. A. (2003). Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc Natl Acad Sci U S A. 25: 14555-61. Bentley S. D., Chater K. F., Cerdeno-Tarraga A. M., Challis G. L., Thomson N. R., James K. D., Harris D. E., Quail M. A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C. W., Collins M., Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C. H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M. A., Rutherford K., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J., Barrell B. G., Parkhill J., Hopwood D.A. (2002). Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 417: 141-7.
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